Los tumores aparecen cuando se lesionan los genes que regulan el crecimiento celular o los que reparan las lesiones de los genes de la célula. Algunas personas pueden nacer con defectos parciales en uno o más de estos genes. En algunos casos estos defectos genéticos son hereditarios y están presentes en más de un miembro de la familia.
Se han comentado en general múltiples factores desde radiación, medio ambiente, contaminación de suelo y agua, sustancias químicas etc… sin embargo hasta el momento, el verdadero origen de las tumoraciones cerebrales se desconoce…
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